ITT5761
ITT5761
- Catalog: ITT5761
- Gene/Protein: WIPI1 WIPI49
- Product Description: Immunotag™ WIPI1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | WIPI1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human(mouse94%) |
| Host Species | Rabbit |
| Immunogen | Synthetic Peptide of WIPI1 |
| Specificity | WIPI1 Polyclonal Antibody detects endogenous levels of WIPI1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | WIPI1 WIPI49 |
| Accession No. | Q5MNZ9 Q8R3E3 |
| Alternate Names | WD repeat domain, phosphoinositide interacting 1 |
| Description | WD repeat domain, phosphoinositide interacting 1(WIPI1) Homo sapiens This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016], |
| Protein Expression | Embryo,Skin,Testis, |
| Subcellular Localization | Golgi membrane,pre-autophagosomal structure,autophagosome membrane,cytoplasm,trans-Golgi network,cytosol,cytoskeleton,endosome membrane,extrinsic component of membrane,clathrin-coated vesicle,pre-autophagosomal stru |
| Protein Function | function:May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.,similarity:Contains 3 WD repeats.,subcellular location:Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles.,subunit:Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes.,tissue specificity:Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|