ITT5971
ITT5971
ITT5971
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- Catalog: ITT5971
- Gene/Protein: LTB TNFC TNFSF3
- Product Description: Immunotag™ LT-β Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein LT-β Clonality Polyclonal Storage/Stability -20°C/1 year Application IHC-p,ELISA Recommended Dilution IHC-p 1:50-200, ELISA 1:10000-20000 Concentration 1 mg/ml Reactive Species Human Host Species Rabbit Immunogen Synthetic peptide from human protein at AA range: 41-90 Specificity The antibody detects endogenous LT-β Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name LTB TNFC TNFSF3 Accession No. Q06643 P41155 Alternate Names Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3) Description lymphotoxin beta(LTB) Homo sapiens Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Cytokine-cytokine receptor interaction, Protein Expression Colon,Peripheral blood leukocyte,Spleen,T-cell, Subcellular Localization extracellular space,plasma membrane,integral component of membrane, Protein Function function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | LT-β |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | IHC-p 1:50-200, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide from human protein at AA range: 41-90 |
| Specificity | The antibody detects endogenous LT-β |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | LTB TNFC TNFSF3 |
| Accession No. | Q06643 P41155 |
| Alternate Names | Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3) |
| Description | lymphotoxin beta(LTB) Homo sapiens Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction, |
| Protein Expression | Colon,Peripheral blood leukocyte,Spleen,T-cell, |
| Subcellular Localization | extracellular space,plasma membrane,integral component of membrane, |
| Protein Function | function:Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.,similarity:Belongs to the tumor necrosis factor family.,subunit:Heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits.,tissue specificity:Spleen and thymus., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |