ITT6073
ITT6073
ITT6073
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$424.00
Price in reward points: 424
- Catalog: ITT6073
- Gene/Protein: GLI1 GLI
- Product Description: Immunotag™ GLI-1 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein GLI-1 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000, ELISA 1:10000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse Host Species Rabbit Immunogen Synthesized peptide derived from human GLI-1. at AA range: 460-490 Specificity This antibody detects endogenous levels of GLI-1 Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name GLI1 GLI Accession No. P08151 P47806 Alternate Names Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) Description GLI family zinc finger 1(GLI1) Homo sapiens This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009], Cell Pathway/ Category Hedgehog,Pathways in cancer,Basal cell carcinoma, Protein Expression Muscle,Whole embryo, Subcellular Localization nucleus,nucleoplasm,cytoplasm,cytosol,axoneme,intracellular membrane-bounded organelle,primary cilium,ciliary tip,ciliary base, Protein Function disease:Defects in GLI1 may be a cause of breast cancer.,function:May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.,induction:Amplified in glioblastoma cells.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subcellular location:Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36.,tissue specificity:Testis, myometrium and fallopian tube., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | GLI-1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human GLI-1. at AA range: 460-490 |
| Specificity | This antibody detects endogenous levels of GLI-1 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GLI1 GLI |
| Accession No. | P08151 P47806 |
| Alternate Names | Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI) |
| Description | GLI family zinc finger 1(GLI1) Homo sapiens This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009], |
| Cell Pathway/ Category | Hedgehog,Pathways in cancer,Basal cell carcinoma, |
| Protein Expression | Muscle,Whole embryo, |
| Subcellular Localization | nucleus,nucleoplasm,cytoplasm,cytosol,axoneme,intracellular membrane-bounded organelle,primary cilium,ciliary tip,ciliary base, |
| Protein Function | disease:Defects in GLI1 may be a cause of breast cancer.,function:May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.,induction:Amplified in glioblastoma cells.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subcellular location:Tethered in the cytoplasm by binding to SUFU. Activation and translocation to the nucleus is promoted by interaction with STK36.,tissue specificity:Testis, myometrium and fallopian tube., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |