ITT6094
ITT6094
ITT6094
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$424.00
Price in reward points: 424
- Catalog: ITT6094
- Gene/Protein: MYL2
- Product Description: Immunotag™ MYL2 Polyclonal Antibody
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Description
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Specifications
Antibody Specification Datasheet 
IMPORTANT NOTE This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. Target Protein MYL2 Clonality Polyclonal Storage/Stability -20°C/1 year Application WB,ELISA Recommended Dilution WB 1:500-2000, ELISA 1:10000-20000 Concentration 1 mg/ml Reactive Species Human,Mouse,Rat Host Species Rabbit Immunogen Synthesized peptide derived from human MYL2. at AA range: 91-140 Specificity MYL2 Polyclonal Antibody detects endogenous levels of MYL2 Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Gene Name MYL2 Accession No. P10916 P51667 Alternate Names Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) Description myosin light chain 2(MYL2) Homo sapiens Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008], Cell Pathway/ Category Cardiac muscle contraction,Focal adhesion,Tight junction,Leukocyte transendothelial migration,Regulates Actin and Cytoskeleton,Hypertrophic cardiomyopathy (HCM),Dilated cardiomyopathy, Protein Expression Cardiac ventricular muscle,Heart,Muscle,Prostate,Skeletal muscle,Striated muscle, Subcellular Localization cytosol,cytoskeleton,actin cytoskeleton,myosin complex,myofibril,sarcomere,A band, Protein Function disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains., Usage For Research Use Only! Not for diagnostic or therapeutic procedures. - Reviews
| Antibody Specification | |
| Datasheet | |
| IMPORTANT NOTE | This product is custom manufactured with a lead time of 3-4 weeks. Once in production, this item cannot be cancelled from an order and is not eligible for return. |
| Target Protein | MYL2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000, ELISA 1:10000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human MYL2. at AA range: 91-140 |
| Specificity | MYL2 Polyclonal Antibody detects endogenous levels of MYL2 |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MYL2 |
| Accession No. | P10916 P51667 |
| Alternate Names | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) |
| Description | myosin light chain 2(MYL2) Homo sapiens Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Cardiac muscle contraction,Focal adhesion,Tight junction,Leukocyte transendothelial migration,Regulates Actin and Cytoskeleton,Hypertrophic cardiomyopathy (HCM),Dilated cardiomyopathy, |
| Protein Expression | Cardiac ventricular muscle,Heart,Muscle,Prostate,Skeletal muscle,Striated muscle, |
| Subcellular Localization | cytosol,cytoskeleton,actin cytoskeleton,myosin complex,myofibril,sarcomere,A band, |
| Protein Function | disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |