Sodium meta-Periodate

Sodium metaperiodate, or sodium m-periodate, is a mild oxidant that is routinely used for the conversion of cis-glycol groups in carbohydrates to reactive aldehdye groups (Figure 1).  The reactive aldehyde groups are used in chemical conjugation procedures or detection of carbohydrates.  For proteomic research, sodium m-periodate is used for the oxidation of the carbohydrate moiety of glycoproteins and offers the advantage of modifying the sugar side chains as opposed to critical amino acids.

• A mild oxidizing agent that converts carbohydrates to activated active aldehydes
• Used in coupling to amines with cyanborohydride reduction
• • Synonyms: Sodium m-periodate, sodium periodate
  • Linear formula:NaIO₄
  • CAS #. 7790-28-5
  • Molecular weight: 213.89
  • Form: White  crystalline powder

Applications

• Oxidation of glycoproteins for coupling chemistry or detection
• For the generation of active aldehydes for reaction with primary amines to form Schiff's base
• For the generation of active aldehydes to react with hydrazide activated molecules, such as HOOK Biotin-Hydrazide