SDS (2 Citations)
Type: Anionic detergent
Full Name: Sodium Dodecyl Sulfate
Molecular Formula: C12H25NaO4S
Molecular Weight: 288.38
Form: White to off white powder
Critical micelle concentration (CMC): 7-10mM (25°C)
Aggregation number: 62
Cloud point: >100°C
Average micellar weight: 18,000
An anionic detergent capable of almost complete disruption of cellular structures and denaturation.
Used for solubilization of a wide variety of proteins, including membrane proteins, for electrophoretic separation.
Detergent molecules tightly bind with the protein molecules masking their native charge and rendering the protein molecules the overall negative charge of the ionic detergent.
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