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ITA2779

ITA2779-1
ITA2779-3
ITA2779-2
ITA2779-1
ITA2779-3
ITA2779-2
  • Gene/Protein: NOD2
  • Product Description: Immunotag™ NOD2 Antibody
  • 280.0000
    Price in reward points: 280

    Available Options

ITA2779

Immunotag™ NOD2 Antibody
Antibody Specification
Datasheet

Target Protein NOD2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC
Recommended Dilution WB 1:500-1:2000, IHC 1:50-1:200
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen A synthesized peptide derived from human NOD2.
Specificity NOD2 antibody detects endogenous levels of NOD2.
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name NOD2
Accession No. Q9HC29
Alternate Names ACUG; Arthrocutaneouveal granulomatosis; BLAU; CARD15; Caspase recruitment domain family, member 15; Caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; CD; CLR16.3; IBD1; Inflammatory bowel disease protein 1; LRR containing protein; NLR family, CARD domain containing 2; NLRC2; NOD like receptor C2; NOD2; NOD2 protein; NOD2_HUMAN; NOD2B; nucleotide binding oligomerization domain 2; Nucleotide binding oligomerization domain containing 2; Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; PSORAS1;
Description Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189).
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 100-110 kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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