ITM1278
ITM1278
- Catalog: ITM1278
- Gene/Protein: ikzf1
- Product Description: Immunotag™ Ikaros(C-term) mouse mAb
405.0000
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Antibody Specification | |
Datasheet | |
Target Protein | Ikaros (C-term) |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IP |
Recommended Dilution | wb 1:1000 |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Purified recombinant human Ikaros(C-terminus) protein fragments expressed in E.coli. |
Specificity | This antibody detects endogenous levels of Ikaros(C-terminus) and does not cross-react with related proteins. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | ikzf1 |
Accession No. | Q13422 Q03267 |
Alternate Names | CLL associated antigen KW 6;DNA-binding protein Ikaros;hIk 1;hIk-1;Hs.54452;IK1;Ikaros (zinc finger protein);IKAROS;IKAROS family zinc finger 1 (Ikaros);Ikaros family zinc finger protein 1;Ikzf1;IKZF1_HUMAN;LYF1;Lymphoid transcription factor LyF-1;PRO0758;Zinc finger protein subfamily 1A 1 (Ikaros);zinc finger protein subfamily 1A 1;Zinc finger protein, subfamily 1A, member 1;ZNFN1A1. |
Description | IKAROS family zinc finger 1(IKZF1) Homo sapiens This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding |
Protein Expression | Bone marrow,Liver,Lymph, |
Subcellular Localization | nucleus,cytoplasm,nuclear pericentric heterochromatin,protein complex, |
Protein Function | function:Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T-cell development.,similarity:Belongs to the Ikaros C2H2-type zinc-finger protein family.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with IKZF4 AND IKZF5.,tissue specificity:Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |