ITM1326
ITM1326
- Catalog: ITM1326
- Gene/Protein: becn1
- Product Description: Immunotag™ Beclin 1 mouse mAb
405.0000
Price in reward points: 405
Your shopping cart is empty!
Antibody Specification | |
Datasheet | |
Target Protein | Beclin 1 |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB |
Recommended Dilution | wb 1:1000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat,Monkey,Hamster |
Host Species | Mouse |
Immunogen | Purified recombinant human Beclin 1 protein fragments expressed in E.coli. |
Specificity | This antibody detects endogenous levels of Beclin 1 and does not cross-react with related proteins. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | becn1 |
Accession No. | Q14457 O88597 |
Alternate Names | APG6;ATG 6;ATG6;ATG6 autophagy related 6 homolog;Bcl-2-interacting protein beclin;Beclin 1 (coiled coil moesin like BCL2 interacting protein);Beclin 1 autophagy related;Beclin-1;Beclin1;BECN 1;BECN1;BECN1_HUMAN;Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein;GT197;Protein GT197;VPS 30;VPS30. |
Description | beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], |
Cell Pathway/ Category | Regulation of autophagy, |
Protein Expression | Brain,Cervix,Mammary gland, |
Subcellular Localization | pre-autophagosomal structure,nucleus,mitochondrion,endosome,autophagosome,endoplasmic reticulum,endoplasmic reticulum membrane,trans-Golgi network,cytosol,endosome membrane,cytoplasmic, membrane-bounded vesicle,extrinsic component of membrane,G |
Protein Function | function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |