ITM3066
ITM3066
- Catalog: ITM3066
- Gene/Protein: ENO2
- Product Description: Immunotag™ NSE Monoclonal Antibody(13E2)
405.0000
Price in reward points: 405
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Antibody Specification | |
Datasheet | |
Target Protein | NSE (13E2) |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IF,IHC-p |
Recommended Dilution | WB: 1:2000 IHC: 1:200 IF 1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Mouse |
Immunogen | Synthetic Peptide of NSE |
Specificity | The antibody detects endogenous NSE proteins. |
Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
Gene Name | ENO2 |
Accession No. | P09104 P17183 P07323 |
Alternate Names | ENO2; Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE |
Description | enolase 2(ENO2) Homo sapiens This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | Glycolysis / Gluconeogenesis,RNA degradation, |
Protein Expression | Amygdala,Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Hematopoietic,Placenta,Retina, |
Subcellular Localization | phosphopyruvate hydratase complex,photoreceptor inner segment,extracellular space,cytosol,plasma membrane,perikaryon,myelin sheath,extracellular exosome, |
Protein Function | catalytic activity:2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.,cofactor:Magnesium. Required for catalysis and for stabilizing the dimer.,developmental stage:During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells.,function:Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.,induction:Levels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jacob disease.,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.,similarity:Belongs to the enolase family.,subcellular location:Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form.,subunit:Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific.,tissue specificity:The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |