ITM3388
ITM3388
- Catalog: ITM3388
- Gene/Protein: TLR1
- Product Description: Immunotag™ TLR1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | TLR1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p |
| Recommended Dilution | IHC: 1:200-500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Recombinant Protein of TLR1 |
| Specificity | The antibody detects endogenous TLR1 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | TLR1 |
| Accession No. | Q15399 Q9EPQ1 |
| Alternate Names | TLR1; KIAA0012; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281 |
| Description | toll like receptor 1(TLR1) Homo sapiens The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Toll_Like, |
| Protein Expression | Bone marrow,Brain,Erythroleukemia,Liver,Lymph,PCR rescued clones, |
| Subcellular Localization | Golgi apparatus,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,phagocytic vesicle membrane,Toll-like receptor 1-Toll-like receptor 2 protein complex,membrane raft, |
| Protein Function | function:Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds MYD88 (via TIR domain) (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.,tissue specificity:Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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