ITN1577
ITN1577
- Catalog: ITN1577
- Gene/Protein: CENPJ CPAP LAP LIP1
- Product Description: Immunotag™ CENPJ Polyclonal Antibody
385.0000
Price in reward points: 385
Your shopping cart is empty!
Antibody Specification | |
Datasheet | |
Target Protein | CENPJ |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from human protein . at AA range: 510-590 |
Specificity | CENPJ Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | CENPJ CPAP LAP LIP1 |
Accession No. | Q9HC77 Q569L8 |
Description | centromere protein J(CENPJ) Homo sapiens This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012], |
Protein Expression | Bone marrow,Epithelium,Lymph node,Muscle,PCR rescued clones,Placenta, |
Subcellular Localization | centrosome,centriole,cytosol,microtubule,gamma-tubulin small complex,ciliary basal body, |
Protein Function | disease:Defects in CENPJ are the cause of primary microcephaly autosomal recessive type 6 (MCPH6) [MIM:608393]. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits.,function:May play an important role in cell division and centrosome function. Inhibits microtubule nucleation from the centrosome.,similarity:Belongs to the TCP10 family.,subcellular location:Localized within the center of microtubule asters.,subunit:Associated with the gamma-tubulin complex. Interacts with the head domain of EPB41. Interacts with LYST., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |