ITN2178
ITN2178
- Catalog: ITN2178
- Gene/Protein: NR5A2 B1F CPF FTF
- Product Description: Immunotag™ NR5A2 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | NR5A2 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Rat,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | NR5A2 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | NR5A2 B1F CPF FTF |
Accession No. | O00482 P45448 Q9QWM1 |
Description | nuclear receptor subfamily 5 group A member 2(NR5A2) Homo sapiens The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016], |
Cell Pathway/ Category | Maturity onset diabetes of the young, |
Protein Expression | Hepatocellular carcinoma,Hepatoma,Liver, |
Subcellular Localization | nucleus,nucleoplasm,cytoplasm,RNA polymerase II transcription factor complex, |
Protein Function | function:Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsable for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR5 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Binds DNA as a monomer (By similarity). Interacts with GRIP1, NCOA2 and NR0B2.,tissue specificity:Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in hepG2. Isoform 1 and isoform 2 seem to be present in fetal and adult liver and hepG2 cells., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |