ITN2375
ITN2375
- Catalog: ITN2375
- Gene/Protein: PTPN14 PEZ
- Product Description: Immunotag™ PTN14 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | PTN14 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from part region of human protein |
Specificity | PTN14 Polyclonal Antibody detects endogenous levels of protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
Gene Name | PTPN14 PEZ |
Accession No. | Q15678 Q62130 |
Description | protein tyrosine phosphatase, non-receptor type 14(PTPN14) Homo sapiens The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010], |
Protein Expression | Epithelium,Heart,Lung,Mammary carcinoma,Pancreas, |
Subcellular Localization | nucleus,nucleoplasm,cytoplasm,cytoskeleton, |
Protein Function | catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Expressed in a variety of human tissues including kidney, skeletal muscle, lung and placenta., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |