ITT0954
ITT0954
- Catalog: ITT0954
- Gene/Protein: CLDN6
- Product Description: Immunotag™ Claudin-6 Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | Claudin-6 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from Claudin-6 . at AA range: 160-240 |
Specificity | Claudin-6 Polyclonal Antibody detects endogenous levels of Claudin-6 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | CLDN6 |
Accession No. | P56747 Q9Z262 |
Alternate Names | CLDN6; Claudin-6; Skullin |
Description | claudin 6(CLDN6) Homo sapiens Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010], |
Cell Pathway/ Category | Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration, |
Protein Expression | Placenta, |
Subcellular Localization | bicellular tight junction,integral component of membrane,apicolateral plasma membrane, |
Protein Function | function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |