ITT1069
ITT1069
- Catalog: ITT1069
- Gene/Protein: COX11
- Product Description: Immunotag™ COX11 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | COX11 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,IF,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human COX11. AA range:51-100 |
Specificity | COX11 Polyclonal Antibody detects endogenous levels of COX11 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | COX11 |
Accession No. | Q9Y6N1 Q6P8I6 |
Alternate Names | COX11; Cytochrome c oxidase assembly protein COX11; mitochondrial |
Description | COX11, cytochrome c oxidase copper chaperone(COX11) Homo sapiens Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to c |
Cell Pathway/ Category | Oxidative phosphorylation, |
Protein Expression | Brain,Cerebellum,Corpus callosum, |
Subcellular Localization | mitochondrion,mitochondrial inner membrane,integral component of membrane, |
Protein Function | function:Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.,similarity:Belongs to the COX11/ctaG family.,subunit:Interacts with CNNM4/ACDP4.,tissue specificity:Ubiquitous., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |