ITT3219
ITT3219
- Catalog: ITT3219
- Gene/Protein: OAT
- Product Description: Immunotag™ OAT Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | OAT |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from OAT, at AA range: 100-180 |
Specificity | OAT Polyclonal Antibody detects endogenous levels of OAT protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | OAT |
Accession No. | P04181 P29758 P04182 |
Alternate Names | OAT; Ornithine aminotransferase; mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase |
Description | ornithine aminotransferase(OAT) Homo sapiens This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010], |
Cell Pathway/ Category | Arginine and proline metabolism, |
Protein Expression | Alzheimer cortex,Brain,Cerebral cortex,Kidney,Liver,Placenta,Subthalamic nucleus,Ut |
Subcellular Localization | mitochondrion,mitochondrial matrix, |
Protein Function | catalytic activity:L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.,cofactor:Pyridoxal phosphate.,disease:Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.,pathway:Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.,similarity:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homotetramer., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |