ITT3566
ITT3566
- Catalog: ITT3566
- Gene/Protein: PTAFR
- Product Description: Immunotag™ PAF-R Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PAF-R |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IF,ELISA |
| Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from PAF-R, at AA range: 170-250 |
| Specificity | PAF-R Polyclonal Antibody detects endogenous levels of PAF-R protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PTAFR |
| Accession No. | P25105 Q62035 P46002 |
| Alternate Names | PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr |
| Description | platelet activating factor receptor(PTAFR) Homo sapiens This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011], |
| Cell Pathway/ Category | Calcium,Neuroactive ligand-receptor interaction, |
| Protein Expression | Brain,Cervix carcinoma,Fetal liver,Granulocyte,Heart ventricle,Leuk |
| Subcellular Localization | nucleoplasm,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,intracellular membrane-bounded organelle, |
| Protein Function | function:Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.,induction:By granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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