Fluorinated surfactants are unable to extract proteins from membrane, but are useful for membrane protein stabilization in subsequent purification steps as they do not strip natural lipids and other co-factors from the proteins. In addition, the bulky fluorinated tails can not penetrate into the interior and disrupt structure. Fluorinated surfactants often decrease non-specific aggregation and are thought to result in improved distribution on cryo-EM grids and better vitrification for cryo-EM data collection. They are also reported to increase crystallizability.
  • Compound Name: FTAC8
  • IUPAC Name: S-(poly(tris(hydroxymethyl)acrylamidomethane)-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorothiodecyl) DPn=12
  • Application: Membrane Protein Stabilization
  • Surfactant type: Fluorinated surfactant
  • Molecular Formula: na
  • Molecular Weight: ~2600 g/mol
  • Percent Composition: na
  • Purity (HPLC, 214nm): nd
  • Retention time (RP18 HPLC): tR = 11.7 min
  • Physical State: White powder
  • Stability: Store in <-20°C freezer for up to one year
  • Solubility: Soluble in water (1mM), methanol and DMSO
  • Critical Micelle Concentration: 0.02 mM

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Material Safety Data Sheet
Catalog Description Size Price(USD) Qty
FTAC8 250 mg