ITA1463
ITA1463
- Catalog: ITA1463
- Gene/Protein: CMKLR1
- Product Description: Immunotag™ CMKLR1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | CMKLR1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500-1:2000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human CMKLR1 |
| Specificity | CMKLR1 Antibody detects endogenous levels of total CMKLR1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | CMKLR1 |
| Accession No. | Q99788 |
| Alternate Names | CHEMERINR; Chemokine like receptor 1; Chemokine-like receptor 1; CHEMR23; CMKLR1; CML1_HUMAN; DEZ; G protein coupled receptor ChemR23; G protein coupled receptor DEZ; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; Orphan G protein coupled receptor; Orphan G protein coupled receptor Dez; Resolvin E1 receptor; RVER1; |
| Description | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 43 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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