ITA2075
ITA2075
- Catalog: ITA2075
- Gene/Protein: CSE1L
- Product Description: Immunotag™ CAS Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | CAS |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human CAS |
| Specificity | CAS Antibody detects endogenous levels of total CAS |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | CSE1L |
| Accession No. | P55060 |
| Alternate Names | CAS; Cellular apoptosis susceptibility protein; Chromosome segregation 1 (yeast homolog) like; Chromosome segregation 1 Like; Chromosome segregation 1 like protein; Chromosome segregation 1-like protein; Chromosome segregation gene CSE1; CSE 1; CSE 1 chromosome segregation 1 like; CSE 1 chromosome segregation 1 like protein; CSE 1L; CSE1; CSE1 chromosome segregation 1 like (yeast); CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1 like protein; CSE1L; Exp 2; Exp2; Exportin 2; Exportin-2; Exportin2; Importin alpha re exporter; Importin-alpha re-exporter; MGC117283; MGC130036; MGC130037; XPO 2; XPO2; XPO2_HUMAN; |
| Description | Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 110kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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