ITA2174
ITA2174
- Catalog: ITA2174
- Gene/Protein: ZC3HC1
- Product Description: Immunotag™ NIPA Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | NIPA |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human NIPA |
| Specificity | NIPA Antibody detects endogenous levels of total NIPA |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | ZC3HC1 |
| Accession No. | Q86WB0 |
| Alternate Names | hNIPA; NIPA_HUMAN; Nuclear interacting partner of ALK; Nuclear interacting partner of anaplastic lymphoma kinase; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; zc3hc1; Zinc finger C3HC type containing 1; Zinc finger C3HC-type protein 1; |
| Description | Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 55kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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