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ITA2360

ITA2360-2
ITA2360-1
ITA2360-3
ITA2360-2
ITA2360-1
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ITA2360
  • Gene/Protein: PPP1R9B
  • Product Description: Immunotag™ NEB2 Antibody
280.0000
Price in reward points: 280

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Immunotag™ NEB2 Antibody
Antibody Specification
Datasheet

Target Protein NEB2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC,ELISA
Recommended Dilution WB 1:1000-3000 IHC 1:200
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen A synthesized peptide derived from human NEB2
Specificity NEB2 Antibody detects endogenous levels of total NEB2
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name PPP1R9B
Accession No. Q96SB3
Alternate Names FLJ30345; NEB2_HUMAN; Neurabin II; Neurabin-2; Neurabin-II; Neurabin2; NeurabinII; Neural tissue specific F actin binding protein II; p130; PP1bp134; PPP1R6; PPP1R9; Ppp1r9b; Protein phosphatase 1 regulatory subunit 9B; SPINO; Spinophilin;
Description Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 89 kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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