ITA2386
ITA2386
- Catalog: ITA2386
- Gene/Protein: DNAJB2
- Product Description: Immunotag™ DNAJB2 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | DNAJB2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human DNAJB2 |
| Specificity | DNAJB2 Antibody detects endogenous levels of total DNAJB2 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | DNAJB2 |
| Accession No. | P25686 |
| Alternate Names | Descriptions; DnaJ (Hsp40) homolog subfamily B member 2; DnaJ homolog subfamily B member 2; DnaJ protein homolog 1; DNAJB2; Heat shock 40 kDa protein 3; Heat shock protein J1; Heat shock protein neuronal DNAJ like 1; HSJ 1; HSJ1; HSPF3; |
| Description | Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family (PubMed:7957263, PubMed:22219199). In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540). Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695). Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 36 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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