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ITA2780

ITA2780-2
ITA2780-1
ITA2780-2
ITA2780-1
ITA2780
  • Gene/Protein: NR1H2
  • Product Description: Immunotag™ NR1H2 Antibody
280.0000
Price in reward points: 280

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Immunotag™ NR1H2 Antibody
Antibody Specification
Datasheet

Target Protein NR1H2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC
Recommended Dilution WB 1:500-1:2000, IHC 1:50-1:200
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat,Pig
Host Species Rabbit
Immunogen A synthesized peptide derived from human NR1H2.
Specificity NR1H2 antibody detects endogenous levels of NR1H2.
Purification The antiserum was purified by peptide affinity chromatography.
Form Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Gene Name NR1H2
Accession No. P55055
Alternate Names Liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; LXR b; LXR beta; LXRB; NER; NER I; NER1; NR1H 2; NR1H2; NR1H2_HUMAN; Nuclear orphan receptor LXR beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; OR-1; Oxysterols receptor LXR-beta; RIP15; Steroid hormone nuclear receptor NER; Ubiquitously-expressed nuclear receptor; UNR;
Description Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
Cell Pathway/ Category Primary Polyclonal Antibody
Protein MW 51 kDa
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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