ITA2852
ITA2852
- Catalog: ITA2852
- Gene/Protein: DNAJB14
- Product Description: Immunotag™ DNAJB14 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | DNAJB14 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC |
Recommended Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human DNAJB14. |
Specificity | DNAJB14 antibody detects endogenous levels of DNAJB14. |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | DNAJB14 |
Accession No. | Q8TBM8 |
Alternate Names | 5730496F10Rik; DJB14_HUMAN; DnaJ (Hsp40) homolog, subfamily B, member 14; DnaJ homolog subfamily B member 14; dnajb14; EGNR9427; FLJ14281; MGC22187; PRO34683; UNQ9427/PRO34683; |
Description | Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 43 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |