ITA3853
ITA3853
- Catalog: ITA3853
- Gene/Protein: RNF20
- Product Description: Immunotag™ RNF20 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | RNF20 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000-3000 ICC/IF |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human RNF20 |
| Specificity | RNF20 Antibody detects endogenous levels of total RNF20 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | RNF20 |
| Accession No. | Q5VTR2 |
| Alternate Names | BRE1 A; BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1-A; BRE1A; BRE1A_HUMAN; E3 ubiquitin-protein ligase BRE1A; hBRE1; Homolog of S. cerevisiae BRE1; RING finger protein 20; Ring finger protein 20 E3 ubiquitin protein ligase; Rnf20; |
| Description | Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 114kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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