ITA4101
ITA4101
- Catalog: ITA4101
- Gene/Protein: PRKAG1
- Product Description: Immunotag™ PRKAG1/2/3 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | PRKAG1/2/3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:500~1:1000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | PRKAG1/2/3 Antibody detects endogenous levels of total PRKAG1/2/3 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | PRKAG1 |
| Accession No. | P54619/Q9UGJ0/Q9UGI9 |
| Alternate Names | 5' AMP activated protein kinase gamma 1 subunit; 5' AMP activated protein kinase subunit gamma 1; 5''-AMP-activated protein kinase subunit gamma-1; AAKG1_HUMAN; AMP activated protein kinase noncatalytic gamma 1 subunit; AMPK gamma 1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg; MGC8666; PRKAG 1; PRKAG1; Protein kinase AMP activated gamma 1 non catalytic subunit; protein kinase, AMP-activated, noncatalytic gamma-1; 5''-AMP-activated protein kinase subunit gamma-2; AAKG; AAKG2; AAKG2_HUMAN; AMPK gamma2; AMPK subunit gamma 2; AMPK subunit gamma-2; CMH6; H91620p; Prkag2; Protein kinase AMP activated gamma 2 non catalytic subunit; WPWS; 5 AMP activated protein kinase subunit gamma 3; 5''-AMP-activated protein kinase subunit gamma-3; AAKG3_HUMAN; AMPK gamma 3 chain; AMPK gamma3; AMPK subunit gamma-3; AMPKG3; PRKAG3; Protein kinase AMP activated gamma 3 non catalytic subunit; |
| Description | AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 38 KD |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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