ITA5372
ITA5372
- Catalog: ITA5372
- Gene/Protein: SESN1
- Product Description: Immunotag™ SESN1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | SESN1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,ELISA |
| Recommended Dilution | WB 1:500~1:1000 IHC: 1:50~1:200 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | SESN1 Antibody detects endogenous levels of total SESN1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | SESN1 |
| Accession No. | Q9Y6P5 |
| Alternate Names | 1110002G11Rik; AU044290; MGC118148; MGC138241; MGC142129; OTTMUSP00000022799; p53 activated gene 26; p53 regulated PA26 nuclear protein; p53 regulated protein PA26; p53-regulated protein PA26; PA26; RP11-787I22.1; sesn1; SESN1_HUMAN; SEST1; sestrin 1; Sestrin-1; |
| Description | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 57 KD |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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