ITA5649
ITA5649
- Catalog: ITA5649
- Gene/Protein: POU4F1
- Product Description: Immunotag™ POU4F1 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | POU4F1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500~1:1000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide |
| Specificity | POU4F1 Antibody detects endogenous levels of total POU4F1 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | POU4F1 |
| Accession No. | Q01851 |
| Alternate Names | Brain specific homeobox/POU domain protein 3A; Brain-3A; Brain-specific homeobox/POU domain protein 3A; Brn 3.0; BRN 3A; Brn-3A; Brn3; BRN3A; class 4; FLJ13449; Homeobox/POU domain protein RDC 1; Homeobox/POU domain protein RDC-1; Homeobox/POU domain protein RDC1; Oct T1; Oct-T1; OctT1; PO4F1_HUMAN; POU class 4 homeobox 1; POU domain; POU Domain Class 4 Transcription Factor 1; Pou4f1; RDC 1; RDC1; transcription factor 1; |
| Description | Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 42 KD |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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