ITA7768
ITA7768
- Catalog: ITA7768
- Gene/Protein: SIAH2
- Product Description: Immunotag™ SIAH2 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | SIAH2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000-3000 IHC 1:200, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human SIAH2 |
| Specificity | SIAH2 Antibody detects endogenous levels of total SIAH2 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | SIAH2 |
| Accession No. | O43255 |
| Alternate Names | E3 ubiquitin protein ligase SIAH2; E3 ubiquitin-protein ligase SIAH1; hSIAH1; hSiah2; HUMSIAH; Seven in absentia homolog 1 (Drosophila); Seven in absentia homolog 1; Seven in Absentia Homolog 2; SIAH 1; Siah 1a; Siah 2; Siah-1; Siah-1a; Siah1; SIAH1_HUMAN; Ubiquitin ligase SIAH1; Ubiquitin Ligase Siah2; |
| Description | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 35 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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