ITA7804
ITA7804
- Catalog: ITA7804
- Gene/Protein: REST
- Product Description: Immunotag™ REST Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | REST |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human REST |
| Specificity | REST Antibody detects endogenous levels of total REST |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | REST |
| Accession No. | Q13127 |
| Alternate Names | Neural Restrictive Silencer Factor; Neural-restrictive silencer factor; Neuron Restrictive Silencer Factor; NRSF; RE1 silencing transcription factor; RE1-silencing transcription factor; Repressor binding to the X2 box; rest; REST protein; REST_HUMAN; X2 box repressor; XBR; |
| Description | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 121 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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