ITA8398
ITA8398
- Catalog: ITA8398
- Gene/Protein: FZD7
- Product Description: Immunotag™ FZD7 Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | FZD7 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IF/ICC,ELISA |
Recommended Dilution | WB 1:1000-3000, IF/ICC 1:100-1:500 |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | A synthesized peptide derived from human FZD7 |
Specificity | FZD7 Antibody detects endogenous levels of total FZD7 |
Purification | The antiserum was purified by peptide affinity chromatography. |
Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
Gene Name | FZD7 |
Accession No. | O75084 |
Alternate Names | Frizzled 7, seven transmembrane spanning receptor; frizzled class receptor 7; Frizzled drosophila homolog of 7; Frizzled family receptor 7; Frizzled homolog 7; Frizzled-7; Frizzled7; Fz 7; Fz-7; Fz7; FZD 7; FZD7; FZD7_HUMAN; FzE 3; FzE3; hFz 7; hFz7; Homolog of Drosophila Frizzled 7; OTTHUMP00000163742; |
Description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Cell Pathway/ Category | Primary Polyclonal Antibody |
Protein MW | 63 kDa |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |