ITA8481
ITA8481
- Catalog: ITA8481
- Gene/Protein: MAPK8IP1
- Product Description: Immunotag™ Phospho-JIP1 (Thr103) Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | Phospho-JIP1 (Thr103) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF/ICC,ELISA |
| Recommended Dilution | WB 1:1000-3000, IF/ICC 1:100-1:500 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human Phospho-JIP1 (Thr103) |
| Specificity | Phospho-JIP1 (Thr103) Antibody detects endogenous levels of JIP1 only when phosphorylated at Thr103 |
| Purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | MAPK8IP1 |
| Accession No. | Q9UQF2 |
| Alternate Names | C jun amino terminal kinase interacting protein 1; C-jun-amino-terminal kinase-interacting protein 1; IB 1; IB-1; IB1; Islet brain 1; Islet-brain 1; JIP 1; JIP-1; JIP1_HUMAN; JNK interacting protein 1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; MAPK8IP 1; MAPK8IP1; MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1; Mitogen activated protein kinase 8 interacting protein 1; Mitogen-activated protein kinase 8-interacting protein 1; PRKM8; PRKM8 interacting protein; PRKM8IP; |
| Description | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 77 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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