ITA8635
ITA8635
- Catalog: ITA8635
- Gene/Protein: WNK2
- Product Description: Immunotag™ WNK2 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
|
| Target Protein | WNK2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human WNK2 |
| Specificity | WNK2 Antibody detects endogenous levels of total WNK2 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | WNK2 |
| Accession No. | Q9Y3S1 |
| Alternate Names | Antigen NY-CO-43; KIAA1760; mitogen-activated protein kinase kinase kinase; NY CO 43; P/OKcl.13; PRKWNK2; Protein kinase lysine deficient 2; Protein kinase with no lysine 2; SDCCAG43; Serine/Threonine protein kinase WNK2; Serologically defined colon cancer antigen 43; WNK lysine deficient protein kinase 2; |
| Description | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 243ka |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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