ITA9339
ITA9339
- Catalog: ITA9339
- Gene/Protein: KHDRBS3
- Product Description: Immunotag™ KHDRBS3 Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet |
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| Target Protein | KHDRBS3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:1000-3000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | A synthesized peptide derived from human KHDRBS3 |
| Specificity | KHDRBS3 Antibody detects endogenous levels of total KHDRBS3 |
| Purification | The antiserum was purified by peptide affinity chromatography. |
| Form | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
| Gene Name | KHDRBS3 |
| Accession No. | O75525 |
| Alternate Names | Etle; etoile; KH domain containing RNA binding signal transduction associated 3; KH domain containing RNA binding signal transduction associated protein 3; KH domain-containing; KHDR3_HUMAN; Khdrbs3; RNA binding protein T Star; RNA-binding; RNA-binding protein T-Star; SALP; Sam68 like mammalian protein 2; Sam68 like phosphotyrosine protein; Sam68 like phosphotyrosine protein T STAR; Sam68-like mammalian protein 2; Sam68-like phosphotyrosine protein; signal transduction-associated protein 3; SLM 2; SLM-2; SLM2; T STAR; TSTAR; |
| Description | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. |
| Cell Pathway/ Category | Primary Polyclonal Antibody |
| Protein MW | 39 kDa |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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