ITC0001
ITC0001
- Catalog: ITC0001
- Gene/Protein: ACR
- Product Description: Immunotag™ Acrosin Polyclonal Antibody
405.0000
Price in reward points: 405
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Antibody Specification | |
Datasheet | |
Target Protein | Acrosin |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from Acrosin . at AA range: 40-120 |
Specificity | Acrosin Polyclonal Antibody detects endogenous levels of Acrosin protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | ACR |
Accession No. | |
Alternate Names | ACR; ACRS; Acrosin |
Description | acrosin(ACR) Homo sapiens Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008], |
Protein Expression | Leukocyte,Testis, |
Subcellular Localization | acrosomal vesicle,extracellular region,nucleus,Golgi-associated vesicle,acrosomal matrix,protein complex, |
Protein Function | catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,function:Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,subunit:Heavy chain (catalytic) and a light chain linked by two disulfide bonds., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |