ITC0072
ITC0072
- Catalog: ITC0072
- Gene/Protein: F2RL3
- Product Description: Immunotag™ Cleaved-PAR-4 (G48) Polyclonal Antibody
460.0000
Price in reward points: 460
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Antibody Specification | |
Datasheet | |
Target Protein | PAR-4 (G48) |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human PAR4. AA range:29-78 |
Specificity | Cleaved-PAR-4 (G48) Polyclonal Antibody detects endogenous levels of fragment of activated PAR-4 protein resulting from cleavage adjacent to G48. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | F2RL3 |
Accession No. | Q96RI0 O88634 |
Alternate Names | F2RL3; PAR4; Proteinase-activated receptor 4; PAR-4; Coagulation factor II receptor-like 3; Thrombin receptor-like 3 |
Description | F2R like thrombin/trypsin receptor 3(F2RL3) Homo sapiens This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016], |
Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
Protein Expression | Lung,Lymphoma, |
Subcellular Localization | extracellular region,plasma membrane,integral component of plasma membrane,integral component of membrane, |
Protein Function | function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |