ITC0079
ITC0079
- Catalog: ITC0079
- Gene/Protein: EFNA5
- Product Description: Immunotag™ Ephrin-A5 Polyclonal Antibody
405.0000
Price in reward points: 405
| Antibody Specification | |
| Datasheet | 
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| Target Protein | EPHrin-A5 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Ephrin-A5, at AA range: 130-210 |
| Specificity | Ephrin-A5 Polyclonal Antibody detects endogenous levels of Ephrin-A5 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | EFNA5 |
| Accession No. | P52803 O08543 P97605 |
| Alternate Names | EFNA5; EPLG7; LERK7; Ephrin-A5; AL-1; EPH-related receptor tyrosine kinase ligand 7; LERK-7 |
| Description | ephrin A5(EFNA5) Homo sapiens Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divi |
| Cell Pathway/ Category | Axon guidance, |
| Protein Expression | Brain, |
| Subcellular Localization | extracellular region,basement membrane,plasma membrane,caveola,adherens junction,membrane,integral component of membrane,anchored component of external side of plasma membrane, |
| Protein Function | function:May function actively to stimulate axon fasciculation. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase.,similarity:Belongs to the ephrin family.,subcellular location:Compartmentalized in discrete caveolae-like membrane microdomains.,subunit:Binds to EPHB2 (By similarity). Binds to the receptor tyrosine kinases EPHA2, EPHA3 and EPHB1., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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