ITK0057
ITK0057
- Catalog: ITK0057
- Gene/Protein: CTTN
- Product Description: Immunotag™ Cortactin (Acetyl Lys235) Polyclonal Antibody
693.0000
Price in reward points: 693
| Antibody Specification | |
| Datasheet | 
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| Target Protein | Cortactin (Lys235) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235. |
| Specificity | Acetyl-Cortactin (K235) Polyclonal Antibody detects endogenous levels of Cortactin protein only when acetylation at K235. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CTTN |
| Accession No. | Q14247 Q60598 |
| Alternate Names | CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1 |
| Description | cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010], |
| Cell Pathway/ Category | Tight junction,Pathogenic Escherichia coli infection, |
| Protein Expression | Coronary artery,Epithelium,Mammary gland,Placenta,Platelet,Testis, |
| Subcellular Localization | ruffle,podosome,cytoplasm,Golgi apparatus,cytoskeleton,actin filament,plasma membrane,clathrin-coated pit,cell-cell adherens junction,focal adhesion,cell cortex,voltage-gated potassium channel complex,lamellipodium,growth |
| Protein Function | function:May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.,online information:Cortactin entry,similarity:Contains 1 SH3 domain.,similarity:Contains 7 cortactin repeats.,subcellular location:Associated with membrane ruffles and lamellipodia.,subunit:Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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