ITK0060
ITK0060
- Catalog: ITK0060
- Gene/Protein: HMGB1
- Product Description: Immunotag™ HMG-1 (Acetyl Lys12) Polyclonal Antibody
693.0000
Price in reward points: 693
| Antibody Specification | |
| Datasheet | 
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| Target Protein | HMG-1 (Lys12) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized acetyl-peptide derived from the N-terminal region of human HMG-1 around the acetylation site of K12. |
| Specificity | Acetyl-HMG-1 (K12) Polyclonal Antibody detects endogenous levels of HMG-1 protein only when acetylation at K12. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | HMGB1 |
| Accession No. | P09429 P63158 P63159 |
| Alternate Names | HMGB1; HMG1; High mobility group protein B1; High mobility group protein 1; HMG-1 |
| Description | high mobility group box 1(HMGB1) Homo sapiens This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015], |
| Cell Pathway/ Category | Base excision repair, |
| Protein Expression | Brain,Cerebellum,Cervix,Epithelium,Mammary carcinoma,Myeloblast cell line,S |
| Subcellular Localization | condensed chromosome,extracellular region,extracellular space,nucleus,nucleoplasm,endosome,early endosome,endoplasmic reticulum-Golgi intermediate compartment,plasma membrane,cell surface,transcriptional repressor complex, |
| Protein Function | function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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