ITK0075
ITK0075
- Catalog: ITK0075
- Gene/Protein: E2F3 KIAA0075
- Product Description: Immunotag™ E2F-3 (Acetyl-Lys168) Polyclonal Antibody
560.0000
Price in reward points: 560
| Antibody Specification | |
| Datasheet | 
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| Target Protein | E2F-3 (Lys168) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB: 1:500-10000 ELISA: 1:10000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human:K168,Mouse:K160,Rat:K161 |
| Host Species | Rabbit |
| Immunogen | Synthesized acetyl-peptide from human protein at AA range: 130-200 |
| Specificity | The antibody detects endogenous E2F-3 (Acetyl-Lys168) protein |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen |
| Form | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Gene Name | E2F3 KIAA0075 |
| Accession No. | O00716 O35261 |
| Alternate Names | E2F3 KIAA0075 |
| Description | E2F transcription factor 3(E2F3) Homo sapiens This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013], |
| Cell Pathway/ Category | Cell_Cycle_G1S,Cell_Cycle_G2M_DNA,Pathways in cancer,Pancreatic cancer,Glioma,Prostate cancer,Melanoma,Bladder cancer,Chronic myeloid leukemia,Small cell lung cancer,Non-small cell lung cancer, |
| Protein Expression | Bone marrow,PCR rescued clones,Placenta,Pre-B cell,Rectum tumor,Uterus, |
| Subcellular Localization | nucleus,nucleoplasm,transcription factor complex,cytoplasm, |
| Protein Function | function:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner.,similarity:Belongs to the E2F/DP family.,subunit:Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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