ITM0020
ITM0020
- Catalog: ITM0020
- Gene/Protein: AKT3
- Product Description: Immunotag™ Akt3 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | AKT3 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of Akt3 expressed in E. Coli. |
| Specificity | Akt3 Monoclonal Antibody detects endogenous levels of Akt3 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | AKT3 |
| Accession No. | Q9Y243 Q9WUA6 |
| Alternate Names | AKT3; PKBG; RAC-gamma serine/threonine-protein kinase; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2 |
| Description | AKT serine/threonine kinase 3(AKT3) Homo sapiens The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Regulation_Microtubule, Stem cell pathway, T_Cell_Receptor, Regulates Angiogenesis, Insulin Receptor, Toll_Like, ErbB/HER, AMPK, MAPK_ERK_Growth,MAPK_G_Protein, B_Cell_Antigen, Adherens_Junction, PI3K/Akt, mTOR |
| Protein Expression | Brain,Eye,Testis, |
| Subcellular Localization | intracellular,nucleoplasm,cytoplasm,Golgi apparatus,plasma membrane, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation.,function:IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation.,subunit:Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.,tissue specificity:In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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