ITM0029
ITM0029
- Catalog: ITM0029
- Gene/Protein: LPA
- Product Description: Immunotag™ ApoA Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ApoA |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of ApoA (4330-4521) expressed in E. Coli. |
| Specificity | ApoA Monoclonal Antibody detects endogenous levels of ApoA protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | LPA |
| Accession No. | P08519 |
| Alternate Names | LPA; Apolipoprotein(a; Apo(a); Lp(a) |
| Description | lipoprotein(a)(LPA) Homo sapiens The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009], |
| Protein Expression | Liver, |
| Subcellular Localization | extracellular region,plasma lipoprotein particle, |
| Protein Function | disease:Elevated plasma concentrations of apo(a) and its naturally occurring proteolytic fragments are correlated with atherosclerosis. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding.,function:Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.,miscellaneous:Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation.,online information:The Singapore human mutation and polymorphism database,polymorphism:The genome version encodes a variant that contains 16 Kringle domains and that lack residues 533 to 3040.,PTM:N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O-glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasminogen subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 38 kringle domains.,subunit:Disulfide-linked to apo-B100. Binds to fibronectin and decorin., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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