ITM0032
ITM0032
- Catalog: ITM0032
- Gene/Protein: APOA4
- Product Description: Immunotag™ ApoA-IV Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ApoA-IV |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of ApoA-IV (aa21-396) expressed in E. Coli. |
| Specificity | ApoA-IV Monoclonal Antibody detects endogenous levels of ApoA-IV protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | APOA4 |
| Accession No. | P06727 P06728 |
| Alternate Names | APOA4; Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4 |
| Description | apolipoprotein A4(APOA4) Homo sapiens Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008], |
| Protein Expression | Brain,Colon,Intestine,Liver, |
| Subcellular Localization | extracellular region,extracellular space,early endosome,endoplasmic reticulum lumen,cytosol,cell surface,very-low-density lipoprotein particle,high-density lipoprotein particle,chylomicron,extracellular exosome,blood microparticle, |
| Protein Function | domain:Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.,function:May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.,online information:The Singapore human mutation and polymorphism database,polymorphism:Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles.,similarity:Belongs to the apolipoprotein A1/A4/E family.,tissue specificity:Synthesized primarily in the intestine and secreted in plasma., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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