ITM0061
ITM0061
- Catalog: ITM0061
- Gene/Protein: BHMT
- Product Description: Immunotag™ BHMT Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | BHMT |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of BHMT expressed in E. Coli. |
| Specificity | BHMT Monoclonal Antibody detects endogenous levels of BHMT protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | BHMT |
| Accession No. | Q93088 O35490 |
| Alternate Names | BHMT; Betaine--homocysteine S-methyltransferase 1 |
| Description | betaine--homocysteine S-methyltransferase(BHMT) Homo sapiens This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Glycine, serine and threonine metabolism,Cysteine and methionine metabolism, |
| Protein Expression | Kidney,Liver,Lung, |
| Subcellular Localization | cytoplasm,cytosol,extracellular exosome, |
| Protein Function | catalytic activity:Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.,cofactor:Binds 1 zinc ion per subunit.,function:Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.,pathway:Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.,pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.,similarity:Contains 1 Hcy-binding domain.,subunit:Homotetramer.,tissue specificity:Found exclusively in liver and kidney., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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