ITM0103
ITM0103
- Catalog: ITM0103
- Gene/Protein: CD14
- Product Description: Immunotag™ CD14 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD14 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,FCM,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human CD14 expressed in E. Coli. |
| Specificity | CD14 Monoclonal Antibody detects endogenous levels of CD14 protein. |
| Purification | Affinity purification |
| Form | Purified antibody in PBS containing 0.03% sodium azide. |
| Gene Name | CD14 |
| Accession No. | P08571 P10810 |
| Alternate Names | CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14 |
| Description | CD14 molecule(CD14) Homo sapiens The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Toll_Like,Hematopoietic cell lineage,Regulates Actin and Cytoskeleton,Pathogenic Escherichia coli infection, |
| Protein Expression | Brain,Glioblastoma,Liver,Lymphocyte,Macrophage,Plasma,Promyelocytic leukemia, |
| Subcellular Localization | extracellular region,extracellular space,Golgi apparatus,plasma membrane,endosome membrane,anchored component of external side of plasma membrane,membrane raft,lipopolysaccharide receptor complex,extracellular exosome, |
| Protein Function | function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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