ITM0116
ITM0116
- Catalog: ITM0116
- Gene/Protein: CD247
- Product Description: Immunotag™ CD3 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD3 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | FCM,ELISA |
| Recommended Dilution | Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of human CD3 expressed in E. Coli. |
| Specificity | CD3 Monoclonal Antibody detects endogenous levels of CD3 protein. |
| Purification | Affinity purification |
| Form | Lyophilized from a 0.2μm filtered solution in PBS. |
| Gene Name | CD247 |
| Accession No. | P20963 P24161 |
| Alternate Names | CD247; CD3Z; T3Z; TCRZ; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain; CD antigen CD247 |
| Description | CD247 molecule(CD247) Homo sapiens The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008], |
| Cell Pathway/ Category | Natural killer cell mediated cytotoxicity,T_Cell_Receptor, |
| Protein Expression | Pancreas,Skeletal muscle,T-cell,Thymus, |
| Subcellular Localization | cytoplasm,plasma membrane,membrane,integral component of membrane,T cell receptor complex,alpha-beta T cell receptor complex, |
| Protein Function | disease:Defects in CD247 are a cause of primary T-cell immunodeficiency [MIM:610163]. Affected individuals suffer of recurrent infections. Patients T-cell counts are very low and B-cell counts are normal.,domain:The ITAM domains mediate interaction with SHB.,function:Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.,online information:CD247 mutation db,PTM:Phosphorylated on Tyr residues after T-cell receptor triggering.,similarity:Belongs to the CD3Z/FCER1G family.,similarity:Contains 3 ITAM domains.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1 Nef protein. Interacts with SHB., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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