ITM0120
ITM0120
- Catalog: ITM0120
- Gene/Protein: CD34
- Product Description: Immunotag™ CD34 Monoclonal Antibody
504.0000
Price in reward points: 504
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CD34 |
| Clonality | Monoclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Mouse |
| Immunogen | Purified recombinant fragment of CD34 expressed in E. Coli. |
| Specificity | CD34 Monoclonal Antibody detects endogenous levels of CD34 protein. |
| Purification | Affinity purification |
| Form | Ascitic fluid containing 0.03% sodium azide. |
| Gene Name | CD34 |
| Accession No. | P28906 Q64314 |
| Alternate Names | CD34; Hematopoietic progenitor cell antigen CD34; CD antigen CD34 |
| Description | CD34 molecule(CD34) Homo sapiens The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011], |
| Cell Pathway/ Category | Cell adhesion molecules (CAMs),Hematopoietic cell lineage, |
| Protein Expression | Bone marrow,Heart,Megakaryoblast,Placenta,Rectum tumor,Skin, |
| Subcellular Localization | cytoplasm,lysosome,plasma membrane,integral component of plasma membrane,external side of plasma membrane,basal plasma membrane,integral component of membrane,apical plasma membrane,glomerular endothelium fenestra,intercellular bridge,perinuclear |
| Protein Function | Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation,developmental stage:On early hematopoietic progenitor cells.,disease:Abnormal CD34 expression in leukemogenesis.,function:Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.,online information:CD34 entry,PTM:Highly glycosylated.,PTM:Phosphorylated on serine residues by PKC.,similarity:Belongs to the CD34 family.,tissue specificity:Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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