ITM0168
ITM0168
- Catalog: ITM0168
- Gene/Protein: CRKL
- Product Description: Immunotag™ Crk-L Monoclonal Antibody
504.0000
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Antibody Specification | |
Datasheet | |
Target Protein | Crk-L |
Clonality | Monoclonal |
Storage/Stability | -20°C/1 year |
Application | WB,FCM,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Mouse |
Immunogen | Purified recombinant fragment of human Crk-L expressed in E. Coli. |
Specificity | Crk-L Monoclonal Antibody detects endogenous levels of Crk-L protein. |
Purification | Affinity purification |
Form | Ascitic fluid containing 0.03% sodium azide. |
Gene Name | CRKL |
Accession No. | P46109 P47941 |
Alternate Names | CRKL; Crk-like protein |
Description | CRK like proto-oncogene, adaptor protein(CRKL) Homo sapiens This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009], |
Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,ErbB_HER,Chemokine,Focal adhesion,Fc gamma R-mediated phagocytosis,Neurotrophin,Regulates Actin and Cytoskeleton,Insulin_Receptor,Pathways in cancer,Renal cell carcinoma,Chronic myeloid leukemia, |
Protein Expression | Skin,Spleen, |
Subcellular Localization | endosome,cytosol,cell-cell adherens junction,extracellular exosome, |
Protein Function | function:May mediate the transduction of intracellular signals.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |